The Buffalo Bills (4-0) take on an AFC East foe when they are at home against the New England Patriots (2-2) on Sunday, October 5, 2025.
If you are looking for Bills vs. Patriots tickets, information is available below.
Buffalo Bills vs. New England Patriots game info
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How to buy Bills vs. Patriots tickets for NFL Week 5
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Buffalo Bills vs. New England Patriots betting odds, lines, spreads
The latest odds can be found below:
Buffalo Bills schedule
- Week 1: Sept. 7 vs. Baltimore Ravens, 41-40 win
- Week 2: Sept. 14 at New York Jets, 30-10 win
- Week 3: Sept. 18 vs. Miami Dolphins, 31-21 win
- Week 4: Sept. 28 vs. New Orleans Saints, 31-19 win
- Week 5: Oct. 5 at 8:20 p.m. ET vs. New England Patriots
- Week 6: Oct. 13 at 7:15 p.m. ET at Atlanta Falcons
- Week 8: Oct. 26 at 1 p.m. ET at Carolina Panthers
- Week 9: Nov. 2 at 4:25 p.m. ET vs. Kansas City Chiefs
- Week 10: Nov. 9 at 1 p.m. ET at Miami Dolphins
- Week 11: Nov. 16 at 1 p.m. ET vs. Tampa Bay Buccaneers
- Week 12: Nov. 20 at 8:15 p.m. ET at Houston Texans
- Week 13: Nov. 30 at 4:25 p.m. ET at Pittsburgh Steelers
- Week 14: Dec. 7 at 4:25 p.m. ET vs. Cincinnati Bengals
- Week 15: Dec. 14 at 1 p.m. ET at New England Patriots
- Week 16: Dec. 21 at 1 p.m. ET at Cleveland Browns
- Week 17: Dec. 28 at 4:25 p.m. ET vs. Philadelphia Eagles
- Week 18: TBD vs. New York Jets
Buffalo Bills stats
- Total offense: 404 yards per game, second in NFL
- Passing offense: 240.5 yards per game, sixth in NFL
- Rushing offense: 163.5 yards per game, first in NFL
- Total defense: 290 yards per game, 11th in NFL
- Passing defense: 125.8 yards per game, first in NFL
- Rushing defense: 164.3 yards per game, 31st in NFL
New England Patriots schedule
- Week 1: Sept. 7 vs. Las Vegas Raiders, 20-13 loss
- Week 2: Sept. 14 at Miami Dolphins, 33-27 win
- Week 3: Sept. 21 vs. Pittsburgh Steelers, 21-14 loss
- Week 4: Sept. 28 vs. Carolina Panthers, 42-13 win
- Week 5: Oct. 5 at 8:20 p.m. ET at Buffalo Bills
- Week 6: Oct. 12 at 1 p.m. ET at New Orleans Saints
- Week 7: Oct. 19 at 1 p.m. ET at Tennessee Titans
- Week 8: Oct. 26 at 1 p.m. ET vs. Cleveland Browns
- Week 9: Nov. 2 at 1 p.m. ET vs. Atlanta Falcons
- Week 10: Nov. 9 at 1 p.m. ET at Tampa Bay Buccaneers
- Week 11: Nov. 13 at 8:15 p.m. ET vs. New York Jets
- Week 12: Nov. 23 at 1 p.m. ET at Cincinnati Bengals
- Week 13: Dec. 1 at 8:15 p.m. ET vs. New York Giants
- Week 15: Dec. 14 at 1 p.m. ET vs. Buffalo Bills
- Week 16: Dec. 21 at 1 p.m. ET at Baltimore Ravens
- Week 17: Dec. 28 at 1 p.m. ET at New York Jets
- Week 18: TBD vs. Miami Dolphins
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New England Patriots stats
- Total offense: 336.3 yards per game, 14th in NFL
- Passing offense: 235 yards per game, seventh in NFL
- Rushing offense: 101.3 yards per game, 25th in NFL
- Total defense: 319 yards per game, 16th in NFL
- Passing defense: 241.5 yards per game, 26th in NFL
- Rushing defense: 77.5 yards per game, second in NFL
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