Patriots at Saints odds, picks and predictions

The New England Patriots (3-2) visit the New Orleans Saints (1-4) Sunday in Week 6. Kickoff from Caesars Superdome in New Orleans, Louisiana, is at 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Patriots vs. Saints odds and make our expert NFL picks and predictions for the best bets.

The Patriots have won 2 straight games and are coming off a 23-20 road win over the previously unbeaten Buffalo Bills Sunday night as 8-point underdogs, with the Under (48.5) cashing. WR Stefon Diggs had 10 receptions for 146 yards, and K Andy Borregales hit a game-winning 52-yard field goal with 15 seconds left in the game.

The Saints picked up their first win of the season last week, beating the New York Giants 26-14 at home as 2.5-point favorites, with the Under (42) cashing. They came back from a 14-3 deficit. QB Spencer Rattler threw an 87-yard TD pass and the defense forced 5 turnovers, returning a fumble for a touchdown.

The Patriots lead the all-time series 10-6, but lost 34-0 at home in the last meeting in 2023.

Play our free daily Pick’em Challenge and win! Play now!

Patriots at Saints odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:58 a.m. ET.

Moneyline (ML): Patriots -190 (bet $190 to win $100) | Saints +155 (bet $100 to win $155)
Against the spread (ATS): Patriots -3.5 (-110) | Saints +3.5 (-110)
Over/Under (O/U): 46 (O: -110 | U: -110)

WIN YOUR FANTASY FOOTBALL LEAGUE! The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Subscribe now!

Patriots at Saints key injuries

Patriots

CB Christian Gonzalez (hamstring) questionable
S Jaylinn Hawkins (hamstring) out
LB Anfernee Jennings (ankle) out
DE Keion White (elbow) out

Saints

RB Alvin Kamara (ankle) questionable
CB Isaac Yiadom (hamstring) out

Patriots at Saints picks and predictions

Prediction

Patriots 31, Saints 20

The Saints had 5 takeaways against the Giants, but in their previous 3 games, they allowed an average of 33.7 points per game. The Patriots put up 42 against the Carolina Panthers and 33 against the Miam Dolphins, so they have the offense to put up points against bad defenses.

Patriots QB Drake Maye had 3 straight games of 2 touchdown passes before playing Buffalo while last week’s win is the only one Rattler has in his career.

You will get better value with the spread to take the Patriots.

PASS.

The Pats have covered the spread in all 3 of their wins this season. All 4 of the Saints’ losses this season have been by more than 4 points.

BET PATRIOTS -3.5 (-110).

The Saints’ 3 games before their win all had totals of 47 or more. Two of the Patriots’ 3 wins had the Over hit.

BET OVER 46 (-110).

FOOTBALL NEVER STOPS: Live games, analysis and more 7 days a week: Get ESPN+!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage: