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Home»NEW ENGLAND SPORTS NEW»Patriots vs. Saints Prediction, Odds, Spread, Injuries, Trends for NFL Week 6
NEW ENGLAND SPORTS NEW

Patriots vs. Saints Prediction, Odds, Spread, Injuries, Trends for NFL Week 6

VermontSportsNewsBy VermontSportsNewsOctober 7, 2025No Comments2 Mins Read
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Patriots vs. Saints Prediction, Odds, Spread, Injuries, Trends for NFL Week 6
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The New England Patriots are coming off one of the biggest upsets of the season, taking down their AFC East rival, the Buffalo Bills.

Now, they’re trying to carry that momentum into their Week 6 game when they take on the New Orleans Saints, who are coming off their first win of the season, taking down the New York Giants.

Let’s dive into the odds and my best bet for this interconference showdown.

Odds via FanDuel Sportsbook

Spread

Moneyline

Total

Patriots Injury Report

Saints Injury Report

Drake Maye has gotten off to an unbelievably strong start to his sophomore season with the New England Patriots. Despite having limited weapons and a terrible offensive line, he has completed 73.9% of passes, averaging 252.2 passing yards per game, along with seven touchdowns through the air.

I’ve been on the “Spencer Rattle isn’t that bad” train for the past two weeks, and the Saints quarterback continues to climb up quarterback rankings, now ranking above the likes of Bo Nix, Justin Herbert, and Jayden Daniels in EPA+CPOE (expected points added + completion percentage over expected). With that being said, I don’t have much faith in the Saints’ defense, so I’m going to bet the OVER in their Week 6 game against the New England Patriots.

The Patriots are built to be the perfect OVER team. The Patriots rank 10th in EPA per play but 23rd in opponent EPA per play. When looking at the advanced metric called DVOA, these two defenses rank 27th and 29th. I’m surprised the total is set in the mid-40s, so give me the OVER.

Pick: OVER 45.5 (-115) via FanDuel

With the latest FanDuel promo code new-user offer, you can place a $5 wager and win $300 in bonus bets. Create your new FanDuel account today to lock in this impressive welcome offer from one of the top sportsbooks in the nation.

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

You can check out all of Iain’s bets here!



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Injuries NFL Odds Patriots prediction Saints spread Trends week
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