Buffalo Bills vs New England Patriots picks, odds for NFL Week 15 game

The Buffalo Bills and New England Patriots play on Sunday, Dec. 14, at the Patriots’ Gillette Stadium in a game on the NFL Week 15 schedule.

Which team will win the NFL Week 15 game?

Check out these NFL Week 15 picks and NFL Week 15 predictions for the game, which can be seen at 11 a.m. MST on CBS (stream with FUBO).

The Bills are a 1-point favorite over the Patriots in NFL Week 15 odds for the game, courtesy of BetMGM Sportsbook.

Buffalo is -115 on the moneyline, while New England is -105. The over/under (point total) is set at 49.5 points.

NFL Week 15 picks: Falcons at Buccaneers | Browns at Bears | Ravens at Bengals | Cardinals at Texans | Jets at Jaguars | Chargers at Chiefs | Bills at Patriots | Commanders at Giants | Raiders at Eagles | Packers at Broncos | Lions at Rams | Panthers at Saints | Colts at Seahawks | Titans at 49ers | Vikings at Cowboys | Dolphins at Steelers | The Republic’s picks

Watch Bills at Patriots live on FUBO (free trial)

Jeremy Cluff writes: “The Patriots have won 10 games in a row. They had a week off to rest for this game. It’s at Gillette Stadium. But Josh Allen will make a big play to win it for Buffalo on the road.”

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Bill Speros writes: “Mike Vrabel is 6-0 as a head coach coming off the bye, winning by an average 30-14 score. That includes a 42-16 win over Sean McDermott’s Bills in 2020. The 11-2 Patriots return to work this week with a share of the best record in the NFL (although they would lose the tiebreaker 11-2 Denver). Buffalo visits New England as the “national” CBS game in the 1 p.m. Sunday time slot. Defending MVP Josh Allen and the Bills lost to New England 23-20 in Week 3. That victory launched Drake Maye’s MVP campaign and draped this version of the Patriots with legitimacy.”

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The site’s formula predicts that the Patriots will win the NFL Week 15 game against the Bills.

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ESPN: Bills have a 52.9% chance to beat Patriots on Sunday

The site gives the Patriots a 46.7% shot at winning the NFL Week 15 game, with the remaining percentage accounting for a tie.

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Dimers: Bills 25, Patriots 23

It writes: “After extensive simulations, our model gives the Bills a win probability of 56%, while the Patriots have a win probability of 44%.”

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Sportsnaut: New England Patriots 24, Buffalo Bills 21

Matt Johnson writes: “The New England Patriots beat the Buffalo Bills earlier this season because of turnovers. Months later, we simply believe the Patriots are the better team. New England is more capable of stopping Buffalo’s rushing attack and Drake Maye can absolutely exploit even a few mistakes made by Buffalo’s defense. It’ll be a great division battle, but the Patriots will complete the season sweep over the Bills.”

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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